"Discovery of Protective Gene Variant Offers Potential Breakthrough in Alzheimer's Treatment"

Researchers at Columbia University have identified a genetic variant that reduces the risk of developing Alzheimer's disease by up to 70% and delays its onset by about four years. The variant occurs in a gene that regulates fibronectin, a component of the blood-brain barrier, and appears to facilitate the clearance of toxic amyloid from the brain. This discovery suggests a new direction for therapeutic development, targeting the blood-brain barrier to prevent or treat Alzheimer's disease. The protective gene was found in individuals resilient to Alzheimer's and may have wide therapeutic potential beyond APOEe4 carriers, offering hope for future treatments.