Unveiling Age-Related Changes in Immune Function Through Multi-Omic and Single-Cell Analyses

This study uses multi-omic profiling over two years to reveal that in healthy adults, immune system changes with age are characterized by stable, transcriptional reprogramming of T cells, a progressive TH2 bias in memory T cells, and altered B cell responses to influenza vaccination, with minimal influence from chronic CMV infection or systemic inflammation prior to advanced age.