"Uncovering the Root of Alzheimer's Vulnerability"

Researchers have identified the DEK gene as potentially responsible for the degeneration of neurons vulnerable to Alzheimer’s Disease (AD), particularly in the entorhinal cortex, a critical area for memory formation. Manipulating DEK levels in experimental models led to increased tau accumulation and neuron degeneration, suggesting a novel therapeutic target. This collaborative effort signifies a crucial step towards understanding and combating the selective vulnerability seen in AD, offering hope for preventing memory loss and curtailing AD progression by protecting these neurons.