Small Cell Lung Cancer Exploits Neuronal Synapses to Promote Tumor Growth

The study reveals that small cell lung cancer (SCLC) forms functional synapses with neurons, particularly glutamatergic ones, which promote tumor growth. These synaptic interactions are characterized by structural and functional evidence of bona fide synapses, including electrophysiological activity and ultrastructural features. Targeting glutamate signaling with drugs like riluzole and DCPG shows promise in reducing tumor growth and improving survival in preclinical models, highlighting a novel neuro-oncological mechanism and potential therapeutic avenue.