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Treatment Target

All articles tagged with #treatment target

health2 years ago•3 min saved

Unveiling a Promising Culprit in Alzheimer's Disease: Brain Autopsies Reveal New Insights

Brain autopsies have revealed that microglia, immune cells responsible for maintaining brain health, behave differently in individuals with Alzheimer's disease compared to those with healthy brains. Researchers found that microglia in Alzheimer's brains were more frequently in a pre-inflammatory state, producing inflammatory molecules that can damage brain cells and contribute to disease progression. The study identified new clusters of microglia with genes involved in inflammation and cell death, suggesting potential targets for new treatments. Understanding the role of microglia in Alzheimer's disease could lead to therapies that prevent or slow the progression of the disease.

via ScienceAlert|

#alzheimers-disease #brain-autopsies #health

health2 years ago•3 min saved

"Genetic Discovery: ALS Onset Delayed by 3 Years with Gene Variant"

A genetic variant that increases the activity of the NEAT1 gene has been found to advance the onset of amyotrophic lateral sclerosis (ALS) by more than three years, according to a study conducted in China. The variant, rs10128627, was associated with an earlier age of onset in a large patient group, with men experiencing onset 2.86 years earlier and women 3.25 years earlier. The NEAT1 gene's exact role in ALS is still unknown, but the findings provide insights into the genetic mechanisms underlying the disease's timing and offer a potential treatment target for delaying onset or slowing progression.

via ALS News Today|

#age-of-onset #als #genetic-variant