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Brain Autopsies

All articles tagged with #brain autopsies

Unveiling a Promising Culprit in Alzheimer's Disease: Brain Autopsies Reveal New Insights
health2 years ago

Unveiling a Promising Culprit in Alzheimer's Disease: Brain Autopsies Reveal New Insights

Brain autopsies have revealed that microglia, immune cells responsible for maintaining brain health, behave differently in individuals with Alzheimer's disease compared to those with healthy brains. Researchers found that microglia in Alzheimer's brains were more frequently in a pre-inflammatory state, producing inflammatory molecules that can damage brain cells and contribute to disease progression. The study identified new clusters of microglia with genes involved in inflammation and cell death, suggesting potential targets for new treatments. Understanding the role of microglia in Alzheimer's disease could lead to therapies that prevent or slow the progression of the disease.

Unveiling a Promising Tool for Early Detection of Alzheimer's Disease During Sleep
health2 years ago

Unveiling a Promising Tool for Early Detection of Alzheimer's Disease During Sleep

Analysis of brain tissue from individuals with Alzheimer's disease has revealed differences in the behavior of immune cells called microglia, indicating a potential new target for treatment. Researchers found that microglia in Alzheimer's brains were more frequently in a pre-inflammatory state, making them less protective. Using a new method to enhance single-nucleus RNA sequencing, the study identified 10 different clusters of microglia, including one that was more common in Alzheimer's patients and had genes associated with inflammation and cell death. The findings suggest that certain microglia clusters may be targets for new therapies to prevent or slow the progression of Alzheimer's disease.