A human clinical trial by Circulate Health and Buck Institute found that therapeutic plasma exchange (TPE), especially when combined with immunoglobulin, can reduce biological age by over 2.5 years, showing promise for aging and longevity interventions.
Covid-19 damages the cells lining the smallest blood vessels, choking off blood flow, leading to organ damage, according to a study. The study found that Covid-19 patients had severely high levels of a blood protein called fibrinogen, causing red blood cells to clump together, altering blood flow and directly damaging the endothelial glycocalyx. The fibrinogen-induced red blood cell aggregation and resulting microvascular damage could be the major pathway by which Covid causes organ damage and even death. The team has done exploratory research using therapeutic plasma exchange to remove plasma with high fibrinogen from Covid-19 patients and replacing it with donor plasma that has normal fibrinogen levels.