All articles tagged with #synaptonemal complex
The study reveals a feedback mechanism where double Holliday junctions (dHJs) and ZMM proteins work together to maintain the synaptonemal complex (SC) during meiosis, ensuring crossover formation and suppressing new DNA double-strand breaks, thereby coordinating meiotic progression and crossover assurance.
Scientists from the Stowers Institute for Medical Research and the Wellcome Center for Cell Biology have identified a potential underlying cause of male infertility. The researchers discovered that a specific mutation in a protein involved in the formation of the synaptonemal complex, a critical structure in the process of sperm and egg cell production, led to infertility in mice. This finding may shed light on similar problems with meiosis in humans and could pave the way for potential treatments.