Tag

Sox17

All articles tagged with #sox17

medical-research1 year ago•26 min saved

"SOX17's Role in Immune Evasion of Colorectal Adenomas and Cancers"

A study has found that SOX17 enables immune evasion in early colorectal adenomas and cancers. The research, which utilized RNA-seq data, ATAC-seq data, and single-cell RNA-seq data, sheds light on the role of SOX17 in immune evasion and its potential implications for colorectal cancer treatment. The findings provide valuable insights into the mechanisms underlying immune evasion in colorectal cancer and may contribute to the development of targeted therapies.

via Nature.com|

#colorectal-cancer #immune-evasion #medical-research

health1 year ago•4 min saved

"Immune Evasion by Early-Stage Cancer Cells"

A new study from MIT and Dana-Farber Cancer Institute has identified a strategy that helps early-stage cancer cells avoid immune detection by turning on a gene called SOX17, making them essentially invisible to the immune system. Blocking SOX17 function or its activating pathway may offer a new way to treat early-stage cancers before they grow into larger tumors. The researchers found that SOX17 prevents cells from synthesizing the receptor that normally detects interferon gamma, a molecule that is one of the immune system’s primary weapons against cancer cells. Knocking out SOX17 in colon tumor organoids allowed the immune system to attack those tumors more effectively, suggesting a potential treatment approach for early-stage colon cancer.

via MIT News|

#cancer #colon-cancer #health