All articles tagged with #rna binding proteins
Aging impairs neurons' ability to respond to stress, leading to mislocalization of key proteins like TDP-43 and destabilizing RNA metabolism, which may contribute to neurodegenerative diseases such as Parkinson's. The study compared lab-grown aged neurons with human brain tissue, revealing chronic stress and protein mislocalization as key features of neuronal aging.
A study by UC San Diego researchers found that aging neurons exhibit molecular stress markers, such as stress granules and TDP-43 accumulation, which impair their ability to recover from stress and may contribute to neurodegenerative diseases like Alzheimer's and ALS. The research highlights potential targets for developing therapies to prevent these conditions.
Researchers at UC San Diego have identified a mechanism that may trigger the early stages of ALS, involving the mislocalization of proteins like CHMP7, which leads to neuron degeneration. By targeting the RNA-binding protein SmD1, they were able to prevent this mislocalization, potentially preserving neuron function. This discovery could lead to therapies that halt ALS progression before significant neurodegeneration occurs, with drugs like risdiplam showing promise in stabilizing neuron integrity.