Tag

Prion Protein

All articles tagged with #prion protein

health1 year ago•2 min saved

"55-Year-Old Michigan Woman Succumbs to 100% Deadly Mad Cow-Like Disease"

A 55-year-old Michigan woman died from Creutzfeldt-Jakob Disease (CJD), a rare and 100% fatal degenerative brain disorder often compared to Mad Cow Disease. CJD, caused by misfolded prion proteins, leads to rapid decline, dementia, and ultimately death with no known cure. Michigan has seen an unusual cluster of CJD cases, prompting urgent investigation. The disease is incredibly rare, affecting one or two per million people annually, with increased risk in older individuals. The husband of the deceased woman is advocating for more research and awareness to find a cure for this aggressive and debilitating disease.

via Daily Mail|

#creutzfeldt-jakob-disease #degenerative-brain-disorder #health

neuroscience2 years ago•4 min saved

Unraveling the Impact of Protein Misfolding on Neurodegeneration

Protein misfolding and deposits in the brain are common factors in neurodegenerative diseases. Recent research explores the phenomenon of cross-seeding, where misfolded proteins from one disease can induce the aggregation of others. A study focused on the interaction between the prion protein and TDP-43 reveals how they collaborate to impact neurodegenerative diseases by triggering the clumping and inactivation of TDP-43. This new mechanism sheds light on how disease-associated prion proteins can affect physiological signaling pathways through cross-seeding.

via Neuroscience News|

#cross-seeding #neurodegenerative-diseases #neuroscience

science2 years ago•2 min saved

Prion protein and copper drive liquid-liquid phase separation in a physics-biology fusion

Researchers from the Federal University of Rio de Janeiro and the German Center for Neurodegenerative Diseases have discovered that the prion protein (PrP) can form dynamic liquid condensates at the cell surface, potentially acting as scavengers for excessive copper ions. The study sheds light on the intricate relationship between PrP and copper ions in live cells and highlights the role of liquid-liquid phase separation in regulating copper homeostasis. The findings have implications for understanding prion diseases and suggest potential interventions targeting copper-bound prion protein condensates to prevent abnormal solid formation and mitigate neurodegenerative outcomes.

via Phys.org|

#cellular-function #copper-ions #liquid-liquid-phase-separation