All articles tagged with #plasmodium falciparum
This study uses dual single-cell RNA sequencing to map the development of P. falciparum in the mosquito midgut, revealing key stages, interactions with mosquito cells, and potential targets for malaria control, including validation of essential parasite genes and discovery of interactions with mosquito progenitor cells and muscles.
Researchers from Leiden University and Radboud University have developed a promising new malaria vaccine that uses genetically weakened Plasmodium falciparum parasites, delivered via mosquito bites, to trigger a strong immune response without causing disease. This second-generation vaccine, GA2, showed significant improvement in protection compared to existing vaccines, with eight out of nine participants protected. The study, published in the New England Journal of Medicine, highlights the potential for more effective malaria prevention, though the mosquito delivery method is not practical for widespread use.