Tag

Orexin

All articles tagged with #orexin

health7 months ago

Sleep Aids and Their Potential Role in Alzheimer’s Prevention

A study in Nature Neuroscience found that lemborexant, a sleep medication, can reduce brain inflammation and tau protein buildup in a mouse model of Alzheimer's, suggesting that targeting sleep-wake systems might help prevent or slow neurodegenerative diseases. The drug improved sleep patterns, decreased tau pathology, and protected brain structure, especially in male mice, highlighting potential for repurposing sleep drugs as disease-modifying therapies. However, further research is needed to confirm these effects in humans and understand sex differences.

neuroscience2 years ago

Orexin's Influence on Pupil Size Revealed

Orexin, not the stress hormone noradrenaline, is responsible for regulating pupil size, challenging previous understanding. Orexin neurons affect pupil size in response to emotional states and mental strain, not just light exposure. This discovery has implications for neurological conditions such as narcolepsy and Alzheimer's, offering new diagnostic avenues. It also sheds light on our understanding of consciousness and attention regulation.