All articles tagged with #nmda receptors
This article presents cryo-EM structures revealing the mechanisms of conductance regulation and neurosteroid binding in NMDA receptors, highlighting different conformational states and the effects of neurosteroids like 24S-HC and EU1622-240 on receptor function.
Researchers at the University at Buffalo have discovered how low-dose ketamine rapidly alleviates depression by selectively targeting specific NMDA receptors in the brain. This binding enhances excitatory transmission and long-term synaptic changes, providing immediate and sustained relief from depressive symptoms. The findings could lead to the development of safer, orally administered ketamine-like drugs, offering new insights into depression treatment and brain disorders.
University at Buffalo neuroscientists have discovered how low-dose ketamine alleviates major depression symptoms by selectively binding to lateral sites on NMDA receptors, enhancing excitatory transmission and promoting synapse formation. This mechanism explains ketamine's rapid and lasting antidepressant effects, distinguishing it from its anesthetic action at higher doses. The findings could lead to the development of ketamine-like drugs with fewer side effects.