All articles tagged with #neoantigens
This study explores how epigenetic changes and immune microenvironment interactions drive early immune evasion in colorectal cancer, highlighting chromatin architecture's role in suppressing neoantigen expression and the importance of early immune escape mechanisms in tumor evolution.
A clinical trial has reported promising results from testing a personalized approach to boosting immune responses to pancreatic tumours. Pancreatic cancers generally don’t respond to immune-checkpoint inhibitors (ICIs) because they express lower levels of neoantigens than other types of tumours, and thus are less likely to activate a strong immune response from antitumour T cells. However, the trial found that a vaccine that boosts T cells that target neoantigens in pancreatic tumours could be effective in treating the disease.