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Microglia Replacement

All articles tagged with #microglia replacement

Replacing Brain Immune Cells Shows Promise for Treating Neurodegenerative Diseases

Originally Published 3 months ago — by Nature

Replacing old microglia with new ones in the brain could offer new treatments for neurological diseases like Alzheimer's and rare genetic disorders, but current methods involve risky procedures like chemotherapy or radiotherapy, limiting their use to severe conditions.

health health brain-immune-cells health microglia microglia-replacement neurodegenerative-diseases therapy

Allogeneic Brain Microglia Replacement for Therapeutic Genetic Restoration

Originally Published 5 months ago — by Nature

The study presents a novel method for replacing brain microglia using allogeneic progenitor cells without the need for myeloablation, successfully treating a mouse model of Sandhoff disease and showing potential for human therapy with induced pluripotent stem cell-derived cells.

health science allogeneic-transplantation brain-microglia genetic-therapy lysosomal-storage-disease microglia-replacement science