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Innate Immune System

All articles tagged with #innate immune system

health1 year ago•4 min saved

Immune System's Role in Cancer Growth Unveiled

New research from Memorial Sloan Kettering Cancer Center reveals that chronic activation of the innate immune system, particularly due to issues in the Mre11 complex, can lead to genome instability and cancer development. This discovery highlights the dual role of the innate immune system in both defending against pathogens and maintaining genome stability. The findings suggest that targeting the immune pathways involved could offer new therapeutic strategies for cancer treatment.

via SciTechDaily|

#cancer #genome-stability #health

neuroscience2 years ago•4 min saved

Targeting Antiviral Pathway for Alzheimer's and Brain Resilience

Inhibiting the cGAS enzyme, which is part of the innate immune system, can help neurons become more resilient to the build-up of tau fibrils, a hallmark of Alzheimer's disease and frontotemporal dementia. This finding may lead to the development of new therapies to deter or delay cognitive decline in these neurodegenerative disorders. The cGAS enzyme triggers the sustained release of the immune system protein type I interferon, which decreases the activity of a protein called MEF2C, a molecular switch that provides neurons with the blueprint to function normally and resist cognitive decline. By inhibiting the antiviral response, researchers were able to turn the switch on to instruct normal neuronal function, even in brains loaded with tau bundles.

via Neuroscience News|

#alzheimers-disease #cgas-enzyme #cognitive-decline