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Indocyanine Green

All articles tagged with #indocyanine green

science2 years ago•3 min saved

"Potential Antidote Found for Deadly Death Cap Mushroom Poisoning"

Scientists have discovered a possible antidote for the world's deadliest mushroom, the death cap mushroom, from a fluorescent dye called indocyanine green (ICG), which is commonly used in medical imaging. The dye stops alpha-amanitin (AMA), the death cap mushroom's primary toxin, dead in its tracks. The antidote has worked in human cells, mini models of the liver, and in mice, but it hasn't been tested in humans. Death cap mushrooms are responsible for 90% of all poisonous mushroom fatalities in humans, and their toxins can cause vomiting, bloody diarrhea or urine, liver and kidney damage, and even death.

via Livescience.com|

#antidote #death-cap-mushroom #indocyanine-green

health2 years ago•2 min saved

Possible Antidote Found for Deadly Mushroom

Scientists have discovered a possible antidote to the deadly toxin of the death cap mushroom, which kills up to 100 people and sickens thousands more each year. Researchers used CRISPR to identify a chemical called indocyanine green (ICG) that can inhibit the mushroom's toxin. When tested on mice, 50% of those that received the ICG antidote survived the toxin, and no side effects were observed. The researchers plan to conduct human trials to assess ICG's efficacy in individuals who have recently ingested toxic mushrooms.

via Yahoo! Voices|

#antidote #crispr #death-cap-mushroom

health2 years ago•3 min saved

Antidote Discovered for World's Deadliest Mushroom

Scientists have identified a substance called indocyanine green that could work as an antidote for poisoning by the deadly death cap mushroom. The candidate is already FDA approved and used as a dye for medical diagnostic imaging. The chemical can reduce the potency of the main death cap toxin, α-amanitin, in human cell lines and mice, effectively blocking α-amanitin-induced cell death. The toxin of the death cap mushroom eats away at the liver, producing symptoms that indicate serious damage to the organ, and can result in failure of the liver and sometimes kidneys, often leading to death.

via ScienceAlert|

#antidote #death-cap-mushroom #health