Researchers developed a prefusion-specific nanobody that neutralizes HSV-1 and HSV-2 by binding to glycoprotein B, preventing its conformational change necessary for viral fusion, with detailed structural insights provided by cryo-EM.
A World Health Organization study reveals that 846 million people globally are infected with genital herpes, a common sexually transmitted infection with no cure. The study highlights the significant prevalence of HSV-1 and HSV-2, with HSV-2 being the primary cause of symptomatic episodes. The infection increases the risk of HIV transmission and poses serious health risks, including neonatal herpes. Despite the economic burden and health challenges, stigma and lack of awareness hinder effective prevention and treatment. WHO calls for urgent development of vaccines and targeted therapies to address this silent epidemic.
A recent survey reveals that over 846 million adults under 50 globally are living with genital herpes, a lifelong sexually transmitted disease caused by herpes simplex virus types 1 and 2. The study highlights the psychological and social challenges faced by those affected, including stigma and mental health issues. Despite the high prevalence, researchers note a decline in genital herpes rates, attributing it to increased STI awareness and safer sexual practices. The findings, published in the journal Sexually Transmitted Infections, emphasize the need for continued public health efforts to manage and reduce the spread of herpes and other STIs.
A new WHO report estimates that over 846 million people aged 15-49 globally have genital herpes, with 42 million new infections annually. While many experience few symptoms, the virus can cause painful sores and increase HIV risk. The report highlights the need for better treatments and vaccines to manage the virus and reduce its spread. Genital herpes, primarily caused by HSV-2, poses significant health and economic burdens, costing an estimated $35 billion annually. WHO emphasizes the importance of awareness, prevention, and research to address this widespread infection.