Research suggests that FDA-approved HIV reverse transcriptase inhibitors may reduce Alzheimer's risk by blocking RT activity in neurons, which is linked to genetic elements called LINE1. RT activity was found in aging and Alzheimer's brains, especially in neurons, and could be targeted for potential treatments to slow or prevent disease progression.
A study utilizing anonymized prescription data from over 225,000 individuals found that HIV-positive patients taking reverse transcriptase (RT) inhibitors showed a significantly lower rate of Alzheimer’s disease (AD) compared to the general population. This discovery builds on previous findings that Alzheimer’s-linked genes might be recombined by enzymes similar to those targeted by HIV treatments. The results could pave the way for new therapeutic strategies using existing drugs to combat the growing AD crisis.
A federal judge in Texas has struck down Affordable Care Act provisions that require health insurers to provide some free preventive care services, jeopardizing coverage nationwide for people relying on the health care law for preventive services such as screenings for cancer as well as HIV drugs. The ruling was based on the judge's previous ruling on the structure of the U.S. Preventive Services Task Force, which was created under Obamacare and helps determine preventive services coverage, saying it violates the appointments clause of the Constitution and thus its related preventive care mandates are unlawful. The plaintiffs who brought the lawsuit objected to purchasing health insurance that provided coverage for those drugs, the human papillomavirus vaccine, contraceptives, and screenings for sexually transmitted diseases because "coverage for those services violates their religious beliefs by making them complicit in facilitating homosexual behavior, drug use, and sexual activity outside of marriage between one man and one woman."