All articles tagged with #glycocalyx
New research shows that immune cells shed a sugar-rich surface layer called glycocalyx to enter inflamed skin in psoriasis, challenging previous beliefs and opening new avenues for treatment targeting immune cell migration.
New research reveals that immune cells shed their glycocalyx layer to facilitate movement into tissues during inflammation, challenging previous beliefs that only blood vessel walls modify their glycocalyx, which could influence future treatments for inflammatory diseases like psoriasis.
Scientists have discovered how cancer cells evade the immune system by developing a barrier called glycocalyx with high levels of cell-surface mucins. The thickness of the barrier affects the antitumor activity of immune cells or engineered cells used for immunotherapy. Researchers used scanning angle interference microscopy to measure the nanoscale dimensions of the cancer cell glycocalyx and engineered immune cells that can get through the barrier, which could enhance current cell-based immunotherapies.