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Genomic Topography

All articles tagged with #genomic topography

science2 years ago•3 min saved

The Impact of DNA's 'Topography' on Cancer-Causing Mutations

The 3D shape and other features of DNA, beyond its genetic code, may influence the accumulation of cancer-causing mutations, according to a study on genomic topography. The study analyzed associations between topographical features of DNA and known patterns of cancer-causing mutations across various cancer types, providing new insights into alcohol-related cancers. The researchers made their data freely available through a database called COSMIC, which could aid in developing targeted cancer treatments. Future research aims to understand why and how DNA's shape influences the development of cancer.

via Livescience.com|

#cancer #dna #genomic-topography

science-and-technology2 years ago•3 min saved

Genome Topography Reveals Surprising Link to Cancer Mutations

Researchers from the University of California San Diego have discovered a connection between the topography of the human genome and the presence of mutations in human cancer. Certain regions of the genome, with unique features, act as hotspots for the accumulation of mutations. The study highlights the potential influence of the human genome's 3D structure in the development of various forms of cancer. The researchers found that mutations linked to alcohol consumption tend to accumulate in regions of the genome that are copied early during cell division, contrary to expectations. Additionally, mutational signatures tied to antiviral activity accumulate in both early- and late-replicated regions of the genome. The findings provide valuable insights for understanding the role of topographical features in cancer development, evolution, and treatment.

via SciTechDaily|

#cancer-mutations #cancer-research #genomic-topography