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Foxo

All articles tagged with #foxo

health1 month ago•5 min saved

Exercise blocks aging muscle decline by silencing a key protein driver

New research shows that exercise helps prevent age-related muscle loss by suppressing the DEAF1 transcription factor that drives protein imbalance and triggering protective FOXO genes, which restore cellular repair and protein recycling. This balances mTORC1 activity to support maintenance rather than degeneration, with both resistance and aerobic training beneficial and a combination offering the greatest benefit. It’s never too late to start—regular activity can help older adults stay stronger and more mobile.

via Medical News Today|

#aging #deaf1 #exercise

neuroscience2 years ago•4 min saved

The Deadly Impact of Witnessing Death on Fruit Flies

Neuroscientists have identified the neural circuits and signaling processes behind the physiological effects, including rapid aging, that occur when fruit flies encounter their dead. They found that a handful of neurons in the Drosophila brain called R2/R4 neurons act as a rheostat for aging. Inhibiting or activating them changed the aging rate of the flies, suggesting that these neurons alter fly life span in response to perceiving dead flies. The study provides insight into the neural underpinnings of how the senses affect aging and could help researchers better understand the physiological and psychological effects of people who routinely witness death.

via The Conversation|

#aging #foxo #fruit-flies