All articles tagged with #cyclic nucleotides
The Panoptes system in bacteria uses decoy cyclic nucleotides to defend against phages by detecting phage anti-defense proteins like Acb2 that sequester these signaling molecules, thereby activating membrane-disrupting effectors to prevent phage replication.
Researchers have determined the structures of a sperm-specific solute carrier, SLC9C1, which plays a crucial role in male fertility. SLC9C1 is unique in its domain composition, containing a transport domain, voltage-sensing domain, and cyclic-nucleotide binding domain. The study provides insights into the overall architecture of SLC9C1 and reveals how the three functional domains are coupled. The findings shed light on the mechanisms by which membrane voltage activates ion exchange in a secondary-active transporter.