All articles tagged with #corneal transplant
A 26-year-old woman, McEwen Baker, shares her emotional journey of gradually losing her vision due to corneal damage and inflammation, undergoing multiple surgeries, and coping with her diagnosis through social media and support groups, highlighting the challenges and resilience involved in her condition.
A 26-year-old woman, McEwen Baker, is documenting her rapid progression to blindness due to corneal cell death and her emotional journey through this life-changing experience, seeking community and support online.
A groundbreaking clinical trial in Japan has successfully used induced pluripotent stem cells (iPSCs) to restore vision in patients with limbal stem cell deficiency (LSCD), a condition causing corneal damage. The trial involved transplanting iPSC-derived corneal epithelial cell sheets onto the corneas of four patients, resulting in significant vision improvements for three of them. This marks a world-first achievement in stem cell research, offering hope for new treatments for corneal vision loss, though further research is needed to ensure safety and efficacy.
Researchers at Osaka University have successfully conducted the first human trial using induced pluripotent stem-cell-derived corneal epithelium to treat limbal stem cell deficiency, a condition causing vision impairment. The study involved transplanting iPSC-derived corneal epithelial sheets onto affected eyes of four patients, resulting in significant vision improvements and enhanced quality of life. This breakthrough offers a promising alternative to traditional treatments, reducing the need for immunosuppression and HLA matching, and marks a significant advancement in regenerative medicine.
A phase 1 clinical trial has shown promising results in using a patient's own stem cells to repair severe eye injuries. Four patients with chemical burns to one eye underwent a therapy called cultivated autologous limbal epithelial cell (CALEC) transplantation, which involved growing a tissue graft from a small biopsy of stem cells taken from the patient's healthy eye. Two patients reported significant improvements in their vision after a year of follow-up, while the other two were able to undergo corneal transplants, which were previously not an option due to the severity of their injuries. The technique offers hope to patients with untreatable vision loss and pain associated with major cornea injuries. Further studies are being conducted to determine the overall efficacy of the procedure.