All articles tagged with #choanoflagellates
The article explores how multicellularity evolved in life on Earth, highlighting research on five simple organisms related to animals, such as choanoflagellates and Capsaspora, which reveal that the molecular toolkit for multicellularity existed long before animals appeared, and that multiple evolutionary paths, including clonal division and aggregation, contributed to this major transition.
Scientists have successfully created a living mouse using stem cells reprogrammed with ancient genes from choanoflagellates, unicellular organisms predating multicellular animals. This breakthrough demonstrates that pluripotency mechanisms existed before animals evolved, challenging previous assumptions about the origins of such genetic tools. The study, led by Ralf Jauch and Alex de Mendoza, highlights the potential of ancient genes in regenerative medicine and evolutionary biology, suggesting that these genetic tools could be harnessed for novel therapeutic strategies.
Scientists have created a mouse using ancient genes from single-celled organisms, challenging previous beliefs about the evolution of stem cells. By introducing choanoflagellate genes into mouse cells, researchers generated induced pluripotent stem cells, which contributed to the development of a chimera mouse. This discovery suggests that key genes involved in stem cell formation may have originated long before multicellular life, offering new insights for regenerative medicine.
Scientists have reprogrammed mouse cells into pluripotent stem cells using a gene from choanoflagellates, demonstrating that key genes for stem cell formation existed in unicellular ancestors nearly a billion years ago. This breakthrough, which led to the creation of a chimeric mouse, redefines the evolutionary origins of stem cells and could inform advancements in regenerative medicine. The study highlights the ancient roots of genetic tools and their potential to optimize stem cell therapies.
Researchers have successfully used genes from choanoflagellates, ancient single-celled relatives of animals, to create mouse stem cells capable of developing into a fully formed mouse. This breakthrough, published in Nature Communications, challenges the belief that key genes for pluripotency evolved exclusively in animals, suggesting they originated much earlier. The study highlights the evolutionary continuity of genetic tools and their potential applications in regenerative medicine, offering insights into optimizing stem cell therapies.