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Chemodynamic Therapy

All articles tagged with #chemodynamic therapy

Dual-ROS Iron MOF Nanotherapy Eradicates Tumors in Mice
health-and-medicine4 hours ago

Dual-ROS Iron MOF Nanotherapy Eradicates Tumors in Mice

OSU researchers developed an iron-based metal-organic framework nanomaterial that, inside tumor cells, catalyzes both hydroxyl radical and singlet oxygen production, delivering a dual ROS attack that eradicated breast cancer tumors in mice with no systemic toxicity and sparing healthy tissue; this chemodynamic therapy approach is being tested on other cancers before advancing to human trials.

Iron MOF Nanoparticles Deliver Dual ROS Assault, Eradicating Tumors in Mice
health23 days ago

Iron MOF Nanoparticles Deliver Dual ROS Assault, Eradicating Tumors in Mice

OSU researchers developed an iron-based metal‑organic framework nanoagent that triggers two reactive oxygen species—hydroxyl radicals and singlet oxygen—in cancer cells, causing oxidative stress and tumor death while largely sparing healthy tissue. In mice with human breast cancer, the nanoagent accumulated in tumors, produced ROS, and achieved complete tumor regression without systemic toxicity, suggesting broad applicability pending human trials.