All articles tagged with #cardiac development
The study identifies HMGN1 as a dosage-sensitive gene on chromosome 21 that influences heart defects in Down syndrome, demonstrating that its increased expression reprograms heart cell identity and that reducing its dosage in mouse models rescues cardiac abnormalities.
Researchers have discovered that a bioelectrical phase transition is responsible for patterning the first heartbeats in vertebrates. Using advanced imaging techniques and optogenetics, the study revealed that calcium signaling plays a crucial role in initiating the heartbeat, preceding cardiac differentiation. The findings provide new insights into the early development of the heart and could have implications for understanding heart defects and potential therapeutic interventions.