All articles tagged with #ampd1
Most modern humans carry a Neanderthal-derived variant of the muscle enzyme AMPD1, which reduces its activity and can slightly limit muscle performance under stress, reflecting an evolutionary legacy that influences traits like athletic ability and energy management.
A study found that a genetic variant inherited from Neanderthals reduces the activity of a key muscle enzyme, AMPD1, by up to 80% in mice and 25% in lab proteins. This variant, present in 2-8% of Europeans, impairs muscle performance but is generally tolerated, and carriers are less likely to reach elite athletic levels. The research highlights the impact of ancient DNA on modern human physiology and performance.
A Neanderthal gene variant affecting the AMPD1 enzyme, which is crucial for muscle energy, was inherited by modern humans and reduces enzyme activity. While generally tolerated, this variant can impair athletic performance, with carriers being less likely to reach top athletic levels. The study highlights the importance of understanding ancient genetic influences on modern physiology and performance.