Tag

Abcb11

All articles tagged with #abcb11

health2 years ago•3 min saved

Early Life Experiences and Genetic Mutations: Unraveling the Roots of Schizophrenia

Researchers have identified two genetic deletions, NRXN1 and ABCB11, associated with schizophrenia that likely occur during early gestation. These deletions, which are not inherited from parents, may contribute to a small but significant part of the genetic architecture of schizophrenia. The findings suggest that the seeds of schizophrenia may be acquired long before birth, opening the door to early prevention strategies. Further research is needed to understand the extent of their contribution to the disorder.

via ScienceAlert|

#abcb11 #early-gestation #genetic-deletions

neuroscience2 years ago•4 min saved

The Genetic Link: Schizophrenia, Cannabis, and Rare Mutations

A study published in Cell Genomics has found a correlation between schizophrenia and somatic copy-number variants (sCNVs), non-inherited genetic mutations that occur early in development. The study analyzed genotype-marker data from over 20,000 blood samples and identified two genes, NRXN1 and ABCB11, that are associated with schizophrenia when disrupted during in-utero development. NRXN1, which helps transmit signals throughout the brain, has been linked to schizophrenia before, but this is the first study to implicate non-inherited mutations. ABCB11, a gene associated with treatment-resistant schizophrenia, also showed correlation, providing new insights into the genetic complexity of the disorder. Further research is needed to identify other acquired mutations associated with schizophrenia and to investigate brain-specific mutations.

via Neuroscience News|

#abcb11 #genetic-mutations #neuroscience