Tag

5 Ht2a Receptor

All articles tagged with #5 ht2a receptor

neuroscience4 hours ago•17 min saved

Psilocybin may trigger long-lasting antidepressant effects by altering neuron firing, not creating new connections

A rat study shows a single dose of psilocybin yields antidepressant-like behavior lasting at least 12 weeks, without lasting spine growth; instead, lasting functional changes in neuron firing (increased excitability and depolarized readiness) in the medial prefrontal cortex likely underlie the effect, with similar results from the 5-HT2A-targeting drug 25CN-NBOH, implicating this receptor; study notes limitations and cautions about translating to humans.

via PsyPost|

#5-ht2a-receptor #antidepressant #functional-plasticity

neuroscience12 days ago•6 min saved

Light-Activated Amino Acids Yield Psychedelic-Style Brain Drugs Without Hallucinations

UC Davis researchers developed a light-driven method that combines amino acids with tryptamine and, after UV exposure, reshapes them into new molecules that activate the serotonin 5-HT2A receptor and may offer psychedelic-like brain benefits without altering perception. In mice, the leading compound fully activated 5-HT2A but did not induce hallucinogenic behaviors (head-twitch responses), leading researchers to pursue further studies on how other serotonin receptors might modulate or suppress perceptual effects.

via SciTechDaily|

#5-ht2a-receptor #drug-discovery #neuroscience