Alzheimer's Progression: From Subtle Beginnings to Rapid Decline

A study of 84 cadaver brains reveals Alzheimer's disease progresses in two phases, with somatostatin inhibitory neurons dying off early. This finding, published in Nature Neuroscience, suggests early intervention could protect these vulnerable neurons, potentially slowing disease progression. The research, supported by the National Institute on Aging, utilized advanced imaging and genetic techniques to track changes in over 3.4 million brain cells, highlighting the importance of inhibitory neurons in maintaining brain function and offering new insights into Alzheimer's treatment strategies.