"Nanosheet Method Revolutionizes Long-Term Brain Imaging"

Researchers have developed a new method called the "nanosheet incorporated into light-curable resin" (NIRE) method for in vivo brain imaging, allowing for large-scale and long-term observation of neuronal structures and activities in awake mice. This method utilizes fluoropolymer nanosheets covered with light-curable resin to create larger cranial windows, enabling high-resolution imaging with sub-micrometer resolution and minimal impact on transparency for over 6 months. The NIRE method provides a powerful tool for investigating neural processes associated with growth, development, learning, and neurological disorders, offering new opportunities to enhance our understanding of the brain's complexity and function.