Uncovering an Ancient Wound Repair Mechanism.

Researchers from Rockefeller University have discovered a new mechanism for wound repair that is distinct from the classical pathway triggered by pathogens. The mechanism is led by interleukin-24 (IL24), which is induced in skin epithelial stem cells at the wound edge. The wound-induced IL24 signaling cascade is independent of germs and is activated by hypoxia caused by blood vessel disruption and scab formation. The researchers found that without IL24 functionality, the healing process was sluggish and delayed. They speculate that IL24 might be involved in the injury response in other body organs featuring epithelial layers.