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Revealing the Ultrafast Calcium Transport Mechanism of Plasma Membrane Ca2+-ATPases

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Source: Nature
Revealing the Ultrafast Calcium Transport Mechanism of Plasma Membrane Ca2+-ATPases
Photo: Nature
TL;DR Summary

This article explores the molecular structure and function of plasma membrane Ca2+-ATPases (PMCAs), revealing how they achieve ultrafast calcium transport through specific structural features, interactions with phospholipids like PtdIns(4,5)P2, and conformational changes during their transport cycle, with implications for understanding their role in cellular calcium signaling and potential drug targeting.

Topics:science#biology#ca2-atpases#cryo-em#molecular-mechanism#plasma-membrane#ptdins45p2
Share this article
  1. Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases  Nature
  2. First comprehensive transport model of a plasma membrane calcium pump could inform new drug development  Phys.org
  3. Ultrafast Plasma Membrane Ca2+ Transport Mechanism  BIOENGINEER.ORG
  4. -pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range  Nature

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