Dominant clones co-opt developmental epigenomics to drive paediatric ependymoma

A multi-omics study in mouse and human ependymoma reveals that ZFTA–RELA fusion co-opts brain-development PLAG/L motif–driven chromatin programs in cycling progenitors to sustain oncogenic gene expression, driving dominant tumor clones that establish the cancer's cellular hierarchy across species; lineage tracing shows early clonal diversity converging on a single dominant lineage, highlighting PLAG/L networks as potential therapeutic targets and suggesting differentiation-based strategies.