Criticality in the Brain: Unlocking Learning and Combating Alzheimer’s

Keith Hengen and colleagues propose that the brain operates optimally at a state called criticality, which is crucial for learning and memory. Disruption of criticality, such as by tau protein buildup in Alzheimer's, impairs cognitive function. The theory suggests new diagnostic and therapeutic approaches, including early detection via fMRI and sleep-based interventions to restore criticality, potentially preventing or slowing neurodegenerative diseases.