Amygdala-Liver Signaling Regulates Stress-Induced Blood Sugar Changes

The study uncovers a novel amygdala–liver pathway that rapidly regulates blood glucose during stress independently of traditional hormonal systems, involving specific neurons in the medial amygdala projecting to the hypothalamus and liver, which are activated by stress and control hepatic glucose production. Repeated stress disrupts this circuit, linking chronic stress to metabolic disorders like type 2 diabetes.