Alzheimer's death switch found, scientists halt it in mice with FP802

Researchers at Heidelberg University have identified a toxic complex formed by NMDA receptors and TRPM4 in the brain that they describe as a death switch driving neuron death in Alzheimer's disease. In mice, they used FP802, a TwinF Interface Inhibitor, to disrupt this complex, which slowed cognitive decline, preserved dendrites and synapses, and reduced amyloid plaques. The findings suggest a new therapeutic approach that targets the death switch rather than amyloid buildup, but human trials are not yet underway and results are limited to animal studies. Development with FundaMental Pharma is progressing toward potential clinical testing.