Unveiling the Structure of the Human Cardiac Myosin Filament

Researchers have used cryo-electron microscopy (cryo-EM) to determine the structure of the human cardiac myosin filament, a key component of muscle contraction in the heart. The study provides insights into the organization and arrangement of proteins within the filament, including myosin heads, tails, titins, and cMyBP-C. The structural data has been deposited in public databases, allowing other scientists to access and analyze the findings. This research contributes to our understanding of the molecular mechanisms underlying heart function and may have implications for the development of treatments for cardiac diseases.