Gene Defect Ties Brain Size to Social Behavior in ASD and Schizophrenia

A study from UT San Antonio links deficits in the Tbx1 gene to reduced brain volume and altered social behavior, relevant to autism and schizophrenia. Tbx1-deficient mice showed smaller amygdala volumes and less interest in social interaction, suggesting genetic variants play a role in brain development and behavior. The research highlights potential early intervention targets for psychiatric disorders by focusing on amygdala shrinkage during embryonic development.