B-cell checkpoint molecules play a crucial role in anti-tumour immunity.

Researchers have identified B-cell-specific checkpoint molecules that regulate anti-tumour immunity. The study found that B-cells play a key role in sustaining inflammation and predicting response to immune checkpoint blockade in human melanoma. The researchers also identified several B-cell-specific checkpoint molecules, including TIM-1, TIGIT, and LAG-3, that could be targeted to enhance anti-tumour immunity. The findings were based on single-cell analysis of tumour samples from patients with melanoma, breast cancer, and colorectal cancer.