Uncovering the Genetic Roots of Age-Related Macular Degeneration

Rare genetic variants that alter the stability of the membrane attack complex (MAC) may drive a chronic inflammatory response in the retina, leading to age-related macular degeneration (AMD). The National Eye Institute (NEI) identified these variants, which could point to a potential therapeutic target to slow or prevent the development of AMD. While there are currently some treatments to slow vision loss for people with the wet form of AMD, there is no treatment for most patients and no cure for the disease.