AI reveals causal gene networks fueling Alzheimer's progression
TL;DR Summary
A new AI-based system called SIGNET maps causal gene regulatory networks across six brain cell types in Alzheimer's brains, revealing extensive gene rewiring—especially in excitatory neurons—and identifying hub genes that could serve as early diagnostic markers or therapeutic targets.
Topics:health#alzheimers-disease#gene-regulation#health-and-medicine#neurons#signet#single-cell-rna-sequencing
- AI uncovers the hidden genetic control centers driving Alzheimer’s ScienceDaily
- Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease Nature
- UC Irvine-led team creates first cell type-specific gene regulatory maps for Alzheimer's disease UC Irvine News
- AI Reveals How Alzheimer’s Rewires the Brain at the Genetic Level SciTechDaily
- UC Irvine Team Develops First Cell Type-Specific Gene Regulatory Maps to Advance Alzheimer’s Research Bioengineer.org
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