Your workouts may prime your brain chemistry, not just your muscles

A 12-week aerobic training program in sedentary adults increased the acute release of brain-derived neurotrophic factor (BDNF) after hard workouts and altered activity in the prefrontal cortex during attention and inhibition tasks. While participants improved their cardiovascular endurance and showed brain signaling changes linked to efficiency, there was no significant improvement in cognitive test scores. The study highlights a potential mechanism by which fitness supports brain function, though it relies on small sample size and maximum-exertion exercise, with serum vs plasma measurements providing different perspectives on BDNF delivery.