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Virus Resistance

All articles tagged with #virus resistance

CRISPR Gene Editing Creates Flu-Resistant Chickens
science-and-technology2 years ago

CRISPR Gene Editing Creates Flu-Resistant Chickens

Scientists have used CRISPR gene-editing technology to create chickens with some resistance to avian influenza, according to a study published in Nature Communications. While the research shows promise, it also highlights the limitations and potential risks of the approach. Breakthrough infections still occurred, especially at high virus doses, and the virus quickly adapted when only one gene was edited. Creating flu-resistant chickens will require editing multiple genes and proceeding carefully to avoid driving further virus evolution. However, if successful, gene-edited chickens could eliminate the need for routine vaccination and provide a new way to make permanent changes in disease resistance.

Harvard scientists engineer virus-proof organism.
science-and-technology2 years ago

Harvard scientists engineer virus-proof organism.

Harvard geneticists have developed a bacteria, E. coli, that is immune to all viruses by altering its genetic code using a special type of RNA called transfer RNA (tRNA). The team added "trickster" tRNAs that install a different amino acid, creating non-functional virus proteins and blocking replication. The bacteria's modified genes cannot escape into the wild due to two safety mechanisms. The research could have implications for bacteria-based production, including the production of biopharmaceuticals, and may provide a general strategy to make any organism safely resistant to all natural viruses.