"Unlocking the Potential: How an Old Drug in Brain's Fluid Shield Offers Hope for Improving Cancer Treatments"
Cerebrospinal fluid, the protective liquid surrounding the brain, may be contributing to the resistance of brain cancers like glioblastoma to standard treatments. Exposure to this fluid causes tumor cells to change and become more resistant to radiation and common medications. However, a decades-old anti-anxiety drug called trifluoperazine shows promise in making these cells more receptive to therapies without harming healthy brain cells. This discovery could lead to the repurposing of trifluoperazine to improve survival rates in glioblastoma patients.