Tag

Tregs

All articles tagged with #tregs

health2 years ago

"Immune Tregs Enhance Stem Cell Therapy for Parkinson's: Study"

Co-transplanting stem cells with regulatory T-cells (Tregs) has been shown to enhance cell survival and alleviate motor symptoms in rodent models of Parkinson's disease. This breakthrough suggests a new strategy to improve clinical outcomes for stem cell-based therapies in humans. The study found that the presence of Tregs increased the survival of transplanted dopamine-producing nerve cells and suppressed the outgrowth of non-dopaminergic cells. These findings have implications for other neurodegenerative disorders and highlight the importance of safety in cell therapy. Future studies are needed to assess the safety and mechanisms of this co-transplantation approach.

health2 years ago

Microparticle therapy reverses MS in mice through immune cell strategy.

Microparticles that activate regulatory T-cells, or Tregs, have shown promise in reversing physical disability due to multiple sclerosis (MS) in a mouse model of the neurodegenerative disorder. The microparticles, called tolerogenic microparticles (Tol-MPs), activate Tregs to help restore tolerance in MS. The particles were tested in mice with experimental autoimmune encephalitis (EAE), a common mouse model of MS, and the treatment immediately reversed the disease in 100% of the mice, with more than a third being cured of their disease. The researchers believe that their microparticle platform could be used to help induce tolerance in other autoimmune diseases.

health2 years ago

SRC-3 gene deletion leads to long-lasting anti-cancer response.

Eliminating the gene SRC-3 in regulatory T cells (Tregs) triggers a lifelong anti-cancer response that eradicates tumors without negative side effects, according to a study by researchers at Baylor College of Medicine. The study shows that Tregs lacking SRC-3 proliferate extensively and infiltrate tumors, releasing compounds that generate an anti-tumor immune response. The modified Tregs block other immune cells that attempt to stop the anti-tumor response. The findings encourage further investigations to determine the value of this approach to treat human cancer.