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Tlr9 Pathway

All articles tagged with #tlr9 pathway

neuroscience1 year ago•5 min saved

"Uncovering the Link Between DNA Damage, Inflammation, and Memory Formation"

Researchers at Albert Einstein College of Medicine have discovered that DNA damage and brain inflammation play crucial roles in the formation of long-term memories within the hippocampus, challenging previous beliefs about inflammation in the brain. The activation of the Toll-Like Receptor 9 (TLR9) pathway following DNA damage in hippocampal neurons was found to be essential for memory encoding, cautioning against indiscriminate inhibition of this pathway due to its importance in memory formation and the potential risks of genomic instability.

via Neuroscience News|

#brain-inflammation #dna-damage #hippocampus

neuroscience1 year ago•3 min saved

"Uncovering the Role of DNA Damage and Inflammation in Long-Term Memory Formation"

Researchers at Albert Einstein College of Medicine have discovered that the formation of long-term memories requires DNA damage and brain inflammation in certain neurons in the brain's hippocampal region. The study found that a stimulus triggers a cycle of DNA damage and repair within these neurons, leading to the formation of stable memory assemblies. The activation of the Toll-Like Receptor 9 (TLR9) pathway, typically involved in immune responses, was found to be essential for this memory-forming mechanism. Inhibiting this pathway not only prevented mice from forming long-term memories but also caused genomic instability, highlighting its potential role in aging and neurodegenerative disorders.

via Medical Xpress|

#brain-inflammation #dna-damage #hippocampal-neurons