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Therapeutic Approach

All articles tagged with #therapeutic approach

health1 year ago•4 min saved

"Revolutionizing Neurodegenerative Disease Treatment with Targeted 'Undruggable' Protein Approach"

Researchers from Northwestern University and the University of Wisconsin-Madison have developed a pioneering approach to combat neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS by targeting the body's antioxidant response. Using protein-like polymers (PLPs) to disrupt the Keap1/Nrf2 protein-protein interaction, the study introduces a promising therapeutic strategy to enhance cellular protection against oxidative stress implicated in these conditions. The innovative PLP technology offers a versatile and effective method for targeting transcription factors and disordered proteins, potentially revolutionizing the development of therapeutics for neurodegenerative diseases.

via Phys.org|

#health #neurodegenerative-diseases #oxidative-stress

health2 years ago•2 min saved

Revolutionary Treatment Approach Unveiled for Osteoarthritis and Neurodegenerative Diseases

Researchers have discovered that elevated levels of the protein c-Fos are associated with the severity of osteoarthritis, a common degenerative joint disease affecting over 500 million people worldwide. This breakthrough provides new insights into potential targeted therapies and challenges the previous belief that osteoarthritis solely stems from wear and tear. The study, led by scientists at MedUni Vienna, found that c-Fos is secreted by cartilage cells in response to osteoarthritis signals and plays a role in protecting cartilage. The research team also deciphered the mechanism controlling the production and accumulation of c-Fos in cartilage cells, paving the way for the development of targeted therapies.

via SciTechDaily|

#cartilage #health #joint-disease

health2 years ago•2 min saved

Revolutionary Approach to Eradicate Aging Cells.

Researchers at Massachusetts General Hospital have discovered that the immune response to a common virus in human tissues can detect and eliminate senescent cells in the skin. Senescent cells are cells that have stopped dividing and are no longer able to perform their normal functions. They accumulate with age and have been linked to a number of age-related diseases, including arthritis, cardiovascular disease, and neurodegeneration. The study highlights a beneficial function of viruses living in our body and could have a variety of clinical applications, including the development of new treatments to eliminate senescent cells in diseases like cancer, fibrosis, and degenerative diseases.

via SciTechDaily|

#aging-cells #health #human-cytomegalovirus